Document Report Card

ID: ALA1123902

Journal: J Med Chem

Title: Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids. The 6-substituted compounds.

Authors: Muchowski JM, Cooper GF, Halpern O, Koehler R, Kluge AF, Simon RL, Unger SH, Van Horn AR, Wren DL, Ackrell J.

Abstract: 5-Aroyl-6-substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carbo xylic acids were synthesized and assayed for analgesic and antiinflammatory activity. Several of these compounds, notably the 5-(4-fluoro- and 4-chlorobenzoyl)-6-methyl derivatives 25 and 26 and the 5-(4-methyl-, 4-fluoro-, 4-chloro-, and 4-methoxybenzoyl)-6-chloro congeners 31-34 were of equal or greater potency than indomethacin as antiinflammatory and analgesic agents both in acute and chronic animal models.

CiteXplore: 3572970

DOI: 10.1021/jm00388a013