Document Report Card

ID: ALA1123969

Journal: J Med Chem

Title: Cardiovascular effects of new water-soluble derivatives of forskolin.

Authors: Khandelwal Y, Rajeshwari K, Rajagopalan R, Swamy L, Dohadwalla AN, de Souza NJ, Rupp RH.

Abstract: A series of 6- and 7-aminoacyl derivatives of 7-deacetylforskolin was prepared to provide water-soluble derivatives of the potent cardioactive diterpenoid forskolin. The compounds were evaluated for positive inotropic and blood pressure lowering properties in pharmacological models. Several derivatives displayed potent positive inotropic activity in guinea pig atria (EC50 = 0.16-3.0 micrograms/mL). In the most active compounds, the amino moiety of the aminoacyl chain corresponded to a cyclic amine, and the acyl moiety to a C2-C4 alkanoyl group. In vivo biological evaluation led to the selection of 6-(piperidinoacetyl)-7-deacetylforskolin hydrochloride (49) as a candidate for clinical development.

CiteXplore: 3172122

DOI: 10.1021/jm00118a002