Document Report Card

ID: ALA1123992

Journal: J Med Chem

Title: Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.

Authors: Peet NP, Dickerson GA, Abdallah AH, Daly JW, Ukena D.

Abstract: 3,5-Dimethylbenzo[1,2-c:5,4-c']dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols. These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors. In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.

CiteXplore: 3172141

DOI: 10.1021/jm00118a032