Document Report Card

ID: ALA1124066

Journal: J Med Chem

Title: Renin inhibitors containing psi[CH2O] pseudopeptide inserts.

Authors: TenBrink RE, Pals DT, Harris DW, Johnson GA.

Abstract: Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1' site, were of a comparable potency to RIP. N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.

CiteXplore: 3279210

DOI: 10.1021/jm00398a029