Document Report Card

ID: ALA1124193

Journal: J Med Chem

Title: Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative.

Authors: Wentland MP, Perni RB, Dorff PH, Rake JB.

Abstract: A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin. The cellular inhibitory and in vivo antibacterial potencies of 1 were found to be less than those of the two reference agents.

CiteXplore: 2842501

DOI: 10.1021/jm00117a005