6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists.

ID: ALA1124200

Journal: J Med Chem

Title: 6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists.

Authors: Flaugh ME, Mullen DL, Fuller RW, Mason NR.

Abstract: A series of 6-substituted tricyclic ergoline partial structures has been synthesized and found to possess very strong serotonin agonist activity. A methoxy group at the 6-position greatly enhances activity, but at the expense of compound stability. Substituting the 6-position with protophyllic groups that are also electron-withdrawing in character enhances both activity and stability.

CiteXplore: 2457705

DOI: 10.1021/jm00117a013

Patent ID: ┄