Syntheses and bioevaluation of substituted dihydropyridines for pregnancy-interceptive activity in hamsters.
Basic Information
ID: ALA1124351
Journal: J Med Chem
Title: Syntheses and bioevaluation of substituted dihydropyridines for pregnancy-interceptive activity in hamsters.
Authors: Mukherjee A, Akhtar MS, Sharma VL, Seth M, Bhaduri AP, Agnihotri A, Mehrotra PK, Kamboj VP.
Abstract: A number of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-substituted-1,4- dihydropyridines were synthesized and evaluated for pregnancy-interceptive activity in mated hamsters. Out of 24 compounds, 12, 15, 21, 22, 28, and 34 caused a marked reduction in the number of implantations when administered on days 3-8 postcoitum. In an in vitro competition assay, none of the compounds exhibited noticeable binding affinity for uterine progesterone receptors. The results reported here have helped to identify new leads for developing pregnancy-interceptive agents and the active compounds do not seem to elicit their interceptive effect through receptor-mediated inhibition of progesterone action in hamster uterus.
CiteXplore: 2795601
DOI: 10.1021/jm00130a012
Patent ID: ┄