Document Report Card

ID: ALA1124369

Journal: J Med Chem

Title: Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents.

Authors: Reich MF, Fabio PF, Lee VJ, Kuck NA, Testa RT.

Abstract: The preparation and biological activities of a series of pyrido[3,4-e]-1,2,4-triazines, 1,2,4-triazino[5,6-c]quinolines, and related fused triazines are described. Methyl, amino, and acylamino substituents were placed in the pyridyl ring of the former system. Other structural modifications included various alkyl, cycloalkyl, substituted phenyl, and heterocyclic groups in the 3-position of these ring systems. In agar dilution assays, actives in this series inhibited strains of Candida, Aspergillus, Mucor, and Trychophyton species at MIC's of less than or equal to 16 micrograms/mL.

CiteXplore: 2810336

DOI: 10.1021/jm00131a010