Document Report Card

ID: ALA1124399

Journal: J Med Chem

Title: Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.

Authors: Diana GD, Cutcliffe D, Oglesby RC, Otto MJ, Mallamo JP, Akullian V, McKinlay MA.

Abstract: A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (MIC) against five rhinovirus serotypes correlated well with log P. The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 microM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.

CiteXplore: 2913305

DOI: 10.1021/jm00122a027