Document Report Card

ID: ALA1124434

Journal: J Med Chem

Title: 2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.

Authors: Hutchison A, Williams M, de Jesus R, Stone GA, Sylvester L, Clarke FH, Sills MA.

Abstract: Two general synthetic approaches to a novel series of 2H-[1]benzopyrano[3,4-b]pyridines are described together with their receptor binding profile at a variety of monoamine receptors in mammalian brain tissue. The biologically active members of this series fall into into one of two broad classes: 3,4,4a,5-tetrahydro-2H-[1]benzopyrano[3,4-b]pyridines or trans-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridines. By appropriate pharmacophoric modification potent selective ligands for D2, alpha-2, 5HT1A, and 5HT2 receptors may be obtained. The previously published in vivo data on certain key representatives of these series are also summarized.

CiteXplore: 2537429

DOI: 10.1021/jm00123a039