Document Report Card

ID: ALA1124605

Journal: J Med Chem

Title: Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives.

Authors: Brewer MD, Burgess MN, Dorgan RJ, Elliott RL, Mamalis P, Manger BR, Webster RA.

Abstract: A series of 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-alpha][2] benzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen. Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b- octahydropyrazino[2,1-alpha][2]benzazepine, epsiprantel (BAN) (22), was selected for further development. The structure-activity relationships are discussed.

CiteXplore: 2769679

DOI: 10.1021/jm00129a007