Document Report Card

ID: ALA1124685

Journal: J Med Chem

Title: Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives.

Authors: Arcamone FM, Animati F, Barbieri B, Configliacchi E, D'Alessio R, Geroni C, Giuliani FC, Lazzari E, Menozzi M, Mongelli N.

Abstract: A group of potential alkylating agents have been synthesized that are structurally related to the oligopeptide antiviral antibiotic distamycin. All derivatives form complexes with native calf-thymus DNA but compounds 2, 3, and 6 give rise to covalent adducts. Cytostatic activity against both human and murine tumor cell lines in vitro is displayed by the new compounds. Compounds 3 and 4 are active on melphalan-resistant L1210 leukemia in mice.

CiteXplore: 2590277

DOI: 10.1021/jm00124a008