Document Report Card

ID: ALA1124760

Journal: J Med Chem

Title: Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines.

Authors: Kelley JL, Linn JA, Selway JW.

Abstract: A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes.

CiteXplore: 2158561

DOI: 10.1021/jm00167a012