Document Report Card

ID: ALA1124788

Journal: J Med Chem

Title: Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.

Authors: Hibert MF, Hoffmann R, Miller RC, Carr AA.

Abstract: A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model.

CiteXplore: 2342053

DOI: 10.1021/jm00168a011