Document Report Card

ID: ALA1124988

Journal: J Med Chem

Title: Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogues of trichostatin A.

Authors: Massa S, Artico M, Corelli F, Mai A, Di Santo R, Cortes S, Marongiu ME, Pani A, La Colla P.

Abstract: A number of aroylpyrroleacrylic acid derivatives were synthesized by standard procedures and evaluated for cytotoxicity in Vero cells and for capacity to inhibit the multiplication of viruses, bacteria, and fungi. While none of the test compounds showed any activity against bacteria and fungi, most of them inhibited the replication of some DNA viruses at concentrations allowing the exponential growth of uninfected cells. In particular three compounds (8, 9c, and 10h) showed an antiviral activity at doses that were from 4- to greater than 8-fold lower than the maximum nontoxic doses.

CiteXplore: 2213836

DOI: 10.1021/jm00172a026