Antitumor properties of tetrahydrobenz[a]anthraquinone derivatives.
Basic Information
ID: ALA1125036
Journal: J Med Chem
Title: Antitumor properties of tetrahydrobenz[a]anthraquinone derivatives.
Authors: Morreal CE, Bernacki RJ, Hillman M, Atwood A, Cartonia D.
Abstract: The compound 8,11-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- 6-methoxy-1,2,3,4-tetrahydro-7,12-benz[a]-anthraquinone (7) was synthesized from 3,6-dimethoxyphthalic anhydride and 6-methoxy-1,2,3,4-tetrahydronaphthalene by a Friedel-Crafts reaction, cyclization to form a dihydroxyanthraquinone, and conversion into the amino-substituted derivative by reaction with 2-[(2-hydroxyethyl)amino]ethylamine. The new compound, a ring D analogue of mitoxantrone, showed growth inhibition, at micromolar concentrations, of murine leukemia 1210, human lung H125, human breast MCF7, human ovary 121, and human colon WiDr and increased the life span of leukemic mice by 38%.
CiteXplore: 2299618
DOI: 10.1021/jm00164a004
Patent ID: ┄