Document Report Card

ID: ALA1125084

Journal: J Med Chem

Title: Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity.

Authors: Forbes IT, Johnson CN, Jones GE, Loudon J, Nicholass JM, Thompson M, Upton N.

Abstract: A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess higher affinity for central benzodiazepine receptors than diazepam, yet show less anticonvulsant activity and are less sedative. The structure-activity relationships of these potential anxiolytic agents are discussed.

CiteXplore: 1975276

DOI: 10.1021/jm00171a046