Basic Information
ID: ALA1125164
Journal: J Med Chem
Title: Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.
Authors: Sarges R, Goldstein SW, Welch WM, Swindell AC, Siegel TW, Beyer TA.
Abstract: A series of spiro hydantoins derived from 8-azachromanones (2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-ones) has been prepared and tested for aldose reductase inhibitory activity. The standard Bucherer-Bergs conditions had to be drastically modified to increase yields from less than 1% to an acceptable 50% range. One of the most potent compounds was cis-6'-chloro-2',3'-dihydro-2'-methylspiro[imidazolidine-4,4'-4'H- pyrano[2,3-b]pyridine]-2,5-dione; resolution of this compound showed that the 2'R,4'S enantiomer 16 was the most active spiro hydantoin in this series with an IC50 of 7.5 x 10(-9) against human placenta aldose reductase.
CiteXplore: 2113948
DOI: 10.1021/jm00169a005
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets