Document Report Card

ID: ALA1125203

Journal: J Med Chem

Title: The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.

Authors: Dyson MR, Coe PL, Walker RT.

Abstract: Starting from benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro- pentofuranoside (4), the following 2'-deoxy nucleoside analogues have been synthesized: 4'-thiothymidine (8), 3'-azido-4'-thio- deoxythymidine (10), and (E)-5-(2-bromovinyl)-4'-thio-2'-deoxyuridine (22). The first compound is toxic, the second is not toxic nor has detectable biological activity, and the third is not toxic and has significant activity against some herpesviruses.

CiteXplore: 1654428

DOI: 10.1021/jm00113a016