Document Report Card

ID: ALA1125241

Journal: J Med Chem

Title: Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.

Authors: Lowe JA, Archer RL, Chapin DS, Chen JB, Helweg D, Johnson JL, Koe BK, Lebel LA, Moore PF, Nielsen JA.

Abstract: A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models predictive of chronic diseases such as depression and inflammation. These results support the hypothesis that inhibition of CaIPDE may lead to useful activity in such chronic diseases.

CiteXplore: 1995886

DOI: 10.1021/jm00106a024