Document Report Card

ID: ALA1125261

Journal: J Med Chem

Title: 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.

Authors: Lowe JA, Seeger TF, Nagel AA, Howard HR, Seymour PA, Heym JH, Ewing FE, Newman ME, Schmidt AW, Furman JS.

Abstract: The design and synthesis of a series of potential atypical antipsychotic agents based on the structure of 1-naphthylpiperazine are described. The incorporation of dopamine antagonist activity into the parent structure was achieved with heterocyclic surrogates for the catechol moiety of dopamine. Compound 4b from this series showed a biochemical profile that translated to behavioral activity in the rat predictive of an antipsychotic agent with a low propensity to cause extrapyramidal side effects in man.

CiteXplore: 1676427

DOI: 10.1021/jm00110a016