Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles.
Basic Information
ID: ALA1125293
Journal: J Med Chem
Title: Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles.
Authors: Venepalli BR, Aimone LD, Appell KC, Bell MR, Dority JA, Goswami R, Hall PL, Kumar V, Lawrence KB, Logan ME.
Abstract: Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative example in this series (5a) established that these compounds are competitive antagonists at the substance P receptor.
CiteXplore: 1370695
DOI: 10.1021/jm00080a025
Patent ID: ┄