Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety.

ID: ALA1125321

Journal: J Med Chem

Title: Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety.

Authors: Blizzard TA, Margiatto GM, Mrozik H, Shoop WL, Frankshun RA, Fisher MH.

Abstract: Chemical conversion of the potent anthelmintic natural products avermectin B1 (1) and avermectin B2 (3) to the corresponding 13-epi analogs (15 and 9) is described. The novel analogs retain the full potency of the natural products but are substantially safer.

CiteXplore: 1433196

DOI: 10.1021/jm00099a014

Patent ID: ┄