Document Report Card

ID: ALA1125325

Journal: J Med Chem

Title: Orally active, nonpeptide oxytocin antagonists.

Authors: Evans BE, Leighton JL, Rittle KE, Gilbert KF, Lundell GF, Gould NP, Hobbs DW, DiPardo RM, Veber DF, Pettibone DJ.

Abstract: The first nonpeptide antagonists of the neurohypophyseal hormone, oxytocin (OT) are described. Derivatives of the spiroindenepiperidine ring system, these compounds include L-366,509, an orally bioavailable OT antagonist with good in vivo duration. The potential use of these agents for treatment of preterm labor and their significance as new nonpeptide ligands for peptide receptors are discussed.

CiteXplore: 1331449

DOI: 10.1021/jm00099a020