Document Report Card

ID: ALA1125538

Journal: J Med Chem

Title: Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.

Authors: So SS, Richards WG.

Abstract: A comparative study of quantitative structure-activity relationships involving diaminopyrimidines as DHFR inhibitors using regression analysis and the neural-network approach suggests that the neural network can outperform traditional methods. The technique permits the highlighting the functional form of those parameters which have an influence on the biological activity.

CiteXplore: 1507206

DOI: 10.1021/jm00095a016