Document Report Card

ID: ALA1125586

Journal: J Med Chem

Title: Novel thiophene-, pyrrole-, furan-, and benzenecarboxamidotetrazoles as potential antiallergy agents.

Authors: Mullican MD, Sorenson RJ, Connor DT, Thueson DO, Kennedy JA, Conroy MC.

Abstract: The synthesis and antiallergic activity of a series of novel thiophene-, pyrrole-, furan-, and benzenecarboxamidotetrazoles are described. A number of compounds inhibit the release of histamine from anti-IgE-stimulated human basophils. Optimal inhibition is exhibited in compounds with a 3-alkoxy, a 4-halo, and a 5-methyl, 5-methoxy, or 5-bromo on a thiophene-2-carboxamidotetrazole.

CiteXplore: 1712394

DOI: 10.1021/jm00111a039