5,5-disubstituted hydantoins: syntheses and anti-HIV activity.
Basic Information
ID: ALA1126132
Journal: J Med Chem
Title: 5,5-disubstituted hydantoins: syntheses and anti-HIV activity.
Authors: Comber RN, Reynolds RC, Friedrich JD, Manguikian RA, Buckheit RW, Truss JW, Shannon WM, Secrist JA.
Abstract: A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone. When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 microM.
CiteXplore: 1404236
DOI: 10.1021/jm00097a014
Patent ID: ┄