Document Report Card

ID: ALA1126288

Journal: J Med Chem

Title: Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors.

Authors: Hubschwerlen C, Pflieger P, Specklin JL, Gubernator K, Gmünder H, Angehrn P, Kompis I.

Abstract: Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported.

CiteXplore: 1315393

DOI: 10.1021/jm00086a006