Document Report Card

ID: ALA1126317

Journal: J Med Chem

Title: 2-(aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents.

Authors: Capps DB, Dunbar J, Kesten SR, Shillis J, Werbel LM, Plowman J, Ward DL.

Abstract: 2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with [(alkylamino)alkyl]hydrazines. Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia. Advanced studies led to the selection of 3bbb for clinical trial.

CiteXplore: 1479579

DOI: 10.1021/jm00104a001