Document Report Card

ID: ALA1126762

Journal: J Med Chem

Title: Synthesis and anaerobic activity of novel 1-carba-1-dethiacephalosporins.

Authors: Ternansky RJ, Jordan CL, Eudaly JA, Kasher JS.

Abstract: The synthesis and biological evaluation of novel 1-carba-1-dethiacephalosporins exhibiting activity against anaerobic pathogens are described. The nitrothiazole substituent was determined to be crucial to maintaining this activity. The pharmacokinetic parameters and initial toxicological profile of the lead compound are discussed.

CiteXplore: 8360877

DOI: 10.1021/jm00068a009