Document Report Card

ID: ALA1126865

Journal: J Med Chem

Title: Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 2. Effect of side-chain modification on in vitro activity and pharmacokinetic parameters.

Authors: Ternansky RJ, Draheim SE, Pike AJ, Counter FT, Eudaly JA, Kasher JS.

Abstract: The structure-activity relationship among a series of novel pyrazolidinone antibacterial agents is described. Specifically, the effect of modification of the side chain attached to the nitrogen at C-7 was explored in an attempt to improve the potency and spectrum of activity. This approach was successful in identifying several compounds having good in vitro profiles. These top candidates were then evaluated for their activity in vivo, and their pharmacokinetic behavior in various animal models was explored. This information proved critical for the identification of candidates for clinical evaluation.

CiteXplore: 8230112

DOI: 10.1021/jm00074a002