Document Report Card

ID: ALA1127066

Journal: J Med Chem

Title: Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus.

Authors: Ternansky RJ, Draheim SE, Pike AJ, Bell FW, West SJ, Jordan CL, Wu CY, Preston DA, Albron W, Kasher JS.

Abstract: The synthesis and antimicrobial activity of several new 1-carba-1-dethiacephalosporins is described. The discovery of unique activity of some of the analogues against methicillin-resistant Staphylococcus aureus led to the development of a structure-activity relationship designed to optimize this activity. The results of this investigation along with the pharmacokinetic characteristics of select compounds are described.

CiteXplore: 8336336

DOI: 10.1021/jm00066a006