Document Report Card

ID: ALA1127528

Journal: J Med Chem

Title: Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides.

Authors: Holmes JM, Lee GC, Wijono M, Weinkam R, Wheeler LA, Garst ME.

Abstract: A series of 4-substituted 2-thiophenesulfonamides was prepared from 3-thiophenecarboxaldehyde using metalation chemistry developed for 3-furaldehyde. Several of these compounds inhibit carbonic anhydrase II in vitro at concentrations of less than 10 nM. In addition, none of these compounds exhibit sensitization potential as determined from in vitro measurement of cysteine reactivity.

CiteXplore: 8201598

DOI: 10.1021/jm00037a015