Document Report Card

ID: ALA1127601

Journal: J Med Chem

Title: Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.

Authors: Niwas S, Chand P, Pathak VP, Montgomery JA.

Abstract: The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.

CiteXplore: 8057293

DOI: 10.1021/jm00041a027