Document Report Card

ID: ALA1127706

Journal: J Med Chem

Title: HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates.

Authors: McKee TC, Cardellina JH, Riccio R, D'Auria MV, Iorizzi M, Minale L, Moran RA, Gulakowski RJ, McMahon JB, Buckheit RW.

Abstract: A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM against HIV-1 (RF) and 2-8 microM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.

CiteXplore: 8145229

DOI: 10.1021/jm00032a012