Synthesis and biological evaluation of novel C-4 aziridine-bearing paclitaxel (taxol) analogs.

ID: ALA1128407

Journal: J Med Chem

Title: Synthesis and biological evaluation of novel C-4 aziridine-bearing paclitaxel (taxol) analogs.

Authors: Chen SH, Fairchild C, Long BH.

Abstract: Three novel C-4 aziridine-bearing paclitaxel analogs, 3-5, have been synthesized during the course of our continuing effort at C-4 modification. The key step in the synthesis is the aziridine ring formation at the C-4 position via an intramolecular Mitsunobu reaction. The syntheses and the biological evaluation of these C-4 aziridine-containing derivatives are herein discussed.

CiteXplore: 7783160

DOI: 10.1021/jm00012a029

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