Pyrazinoic acid esters with broad spectrum in vitro antimycobacterial activity.
Basic Information
ID: ALA1128446
Journal: J Med Chem
Title: Pyrazinoic acid esters with broad spectrum in vitro antimycobacterial activity.
Authors: Cynamon MH, Gimi R, Gyenes F, Sharpe CA, Bergmann KE, Han HJ, Gregor LB, Rapolu R, Luciano G, Welch JT.
Abstract: A series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the ester functionality have been very successful in expanding the activity of pyrazinamide to include M. avium and M. kansasii, organisms normally not susceptible to pyrazinamide. Several of these compounds have activities 100-1000-fold greater than that of pyrazinamide against M. tuberculosis.
CiteXplore: 7562923
DOI: 10.1021/jm00020a003
Patent ID: ┄