Document Report Card

ID: ALA1129061

Journal: J Med Chem

Title: Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies.

Authors: Schönleben-Janas A, Kirsch P, Mittl PR, Schirmer RH, Krauth-Siegel RL.

Abstract: A series of newly synthesized N(10)-arylisoalloxazines--some of which are known to be antimalarial agents--were studied as inhibitors of human glutathione reductase (GR;NADPH + GSSG + H(+) <==> NADP(+) + 2GSH). The flavoenzyme was inhibited with IC(50) values between

CiteXplore: 8691487

DOI: 10.1021/jm950511+