Document Report Card

ID: ALA1129322

Journal: J Med Chem

Title: Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.

Authors: Riechers H, Albrecht HP, Amberg W, Baumann E, Bernard H, Böhm HJ, Klinge D, Kling A, Müller S, Raschack M, Unger L, Walker N, Wernet W.

Abstract: A novel class of endothelin-A receptor ligands was discovered by high-throughput screening. Lead structure optimization led to highly potent antagonists which can be synthesized in a short sequence. The compounds are endothelin-A-selective, are orally available, and show a long duration of action.

CiteXplore: 8667356

DOI: 10.1021/jm960274q