Document Report Card

ID: ALA1129484

Journal: J Med Chem

Title: Selectively cytotoxic diterpenes from Euphorbia poisonii.

Authors: Fatope MO, Zeng L, Ohayaga JE, Shi G, McLaughlin JL.

Abstract: Bioactivity-guided fractionation of the latex of Euphorbia poisonii Pax. (Euphorbiaceae) led to the isolation and characterization of a new tigliane diterpene, 12-deoxyphorbol 13-(9,10-methylene)undecanoate (3), together with five known diterpenes (1,2,4-6). When evaluated for cytotoxicity in a panel of six human solid tumor cell lines, the diterpene esters, 1-3, 5, and 6, were selectively cytotoxic for the human kidney carcinoma (A-498) cell line with potencies for 2 and 3 exceeding that of adriamycin by ten thousand times. Details of the isolations, structural analyses, and cytotoxic activities are described.

CiteXplore: 8632402

DOI: 10.1021/jm950509i