Document Report Card

Basic Information

ID: ALA1129528

Journal: J Med Chem

Title: Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors.

Authors: Kiefel MJ, Beisner B, Bennett S, Holmes ID, von Itzstein M.

Abstract: Rotavirus can cause severe gastrointestinal disease, especially in infants and young children, and is particularly prevalent in Third-World countries. Therefore, the development of potential inhibitors of this virus is of great interest. The present study describes the synthesis and in vitro biological evaluation of a number of N-acetylneuraminic acid-based compounds as potential rotavirus inhibitors. Our data suggests that it is indeed possible to inhibit adhesion of the virus, and hence in vitro replication, with carbohydrate-based molecules, although this inhibition does appear to be strain dependent.

CiteXplore: 8632438

DOI: 10.1021/jm950611f