Document Report Card

ID: ALA1129947

Journal: J Med Chem

Title: (+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent.

Authors: Seley KL, Schneller SW, Rattendi D, Bacchi CJ.

Abstract: The (+)-enantiomer of 7-deaza-5'-noraristeromycin (4) has been found to show IC50 values ranging from 0.16 to 5.3 microM against four strains of African trypanosomes, one Trypanosoma brucei brucei isolate, and several clinical isolates of Trypanosoma brucei rhodesiense (agent of east African sleeping sickness), including a multidrug resistant clone of one isolate. While this compound was originally designed to inhibit S-adenosyl-L-homocysteine hydrolase, it has been found to have no effect on this enzyme.

CiteXplore: 9046353

DOI: 10.1021/jm9605039