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ID: ALA1130607
Journal: Bioorg Med Chem Lett
Title: Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids.
Authors: Kam TS, Subramaniam G, Sim KM, Yoganathan K, Koyano T, Toyoshima M, Rho MC, Hayashi M, Komiyama K.
Abstract: A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsilongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-delta 16,17-kopsinine were found to show appreciable activity.
CiteXplore: 9873619