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ID: ALA1130613
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.
Authors: Roush WR, González FV, McKerrow JH, Hansell E.
Abstract: The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec-1M-1.
CiteXplore: 9873627