S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase.

ID: ALA1130617

Journal: Bioorg Med Chem Lett

Title: S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase.

Authors: Drysdale MJ, Reinhard JF.

Abstract: A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynthesis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages.

CiteXplore: 9871640

DOI: 10.1016/s0960-894x(97)10209-8

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