Basic Information
ID: ALA1130620
Journal: Bioorg Med Chem Lett
Title: New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
Authors: Ojima I, Bounaud PY, Takeuchi C, Pera P, Bernacki RJ.
Abstract: New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
CiteXplore: 9871652
DOI: 10.1016/s0960-894x(97)10218-9
Patent ID: ┄
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