Document Report Card

Basic Information

ID: ALA1130652

Journal: Bioorg Med Chem Lett

Title: Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.

Authors: Baraldi PG, Cacciari B, Guiotto A, Leoni A, Romagnoli R, Spalluto G, Mongelli N, Howard PW, Thurston DE, Bianchi N, Gambari R.

Abstract: We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11.

CiteXplore: 9873668

DOI: 10.1016/s0960-894x(98)00544-7