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ID: ALA1130669
Journal: Bioorg Med Chem Lett
Title: Resveratrol as a new type of DNA-cleaving agent.
Authors: Fukuhara K, Miyata N.
Abstract: The first demonstration of DNA cleavage by resveratrol '3,5,4'-trihydroxy-trans-stilbene' is presented. Resveratrol mediated relaxation of pBR322 at micromolar concentrations in the presence of Cu2+. Evidence is provided that resveratrol is capable of binding to DNA, and that the Cu(2+)-dependent DNA damage is more likely caused by a copper-peroxide complex rather than by a freely diffusible oxygen species.
CiteXplore: 9873700