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ID: ALA1130691
Journal: Bioorg Med Chem Lett
Title: Acceptor substrate-based selective inhibition of galactosyltransferases.
Authors: Chung SJ, Takayama S, Wong CH.
Abstract: This paper describes the discovery of glycosyl acceptor analogs as potent and selective inhibitors of alpha-1,3- and beta-1,4-galactosyltransferases. Incorporation of an appropriate aromatic group to the aglycon position of the enzyme's acceptors results in a strong inhibition, representing the first and most potent small uncharged molecules as selective inhibitors of these two enzymes and thus providing a new strategy for the development of selective glycosyltransferase inhibitors.
CiteXplore: 9873734