Document Report Card
Basic Information
ID: ALA1130693
Journal: Bioorg Med Chem Lett
Title: Inhibition of topoisomerase I by naphthoquinone derivatives.
Authors: Plyta ZF, Li T, Papageorgiou VP, Mellidis AS, Assimopoulou AN, Pitsinos EN, Couladouros EA.
Abstract: Alkannin and shikonin are naturally occurring naphthoquinones. We have tested several derivatives of the title compounds and we have found that naphthoquinones bearing at least one phenolic hydroxyl group are potent inhibitors of topoisomerase I. The ability of the tested compounds to complex Zn++ parallels with a few exceptions their topoisomerase I inhibition properties while their intercalation and redox properties do not.
CiteXplore: 9873739